Appetite-suppressing effect of physical activity

28/10/2025

To stay healthy, it is advisable to eat a balanced diet and exercise regularly. When losing weight, physical exercise is certainly beneficial because it burns calories, but a recent study indicates that it also has the effect of reducing appetite after exercise.

During exercise, the body can produce 𝐥𝐚𝐜𝐭𝐚𝐭𝐞 𝐭𝐡𝐫𝐨𝐮𝐠𝐡 𝐚𝐧𝐚𝐞𝐫𝐨𝐛𝐢𝐜 𝐠𝐥𝐲𝐜𝐨𝐥𝐲𝐬𝐢𝐬. Lactate is well known because it can turn into 𝐥𝐚𝐜𝐭𝐢𝐜 𝐚𝐜𝐢𝐝 and cause 𝐩𝐚𝐢𝐧 𝐚𝐧𝐝 𝐜𝐫𝐚𝐦𝐩𝐬 when it is not eliminated by the body. However, an article published in 𝑁𝑎𝑡𝑢𝑟𝑒 𝑀𝑒𝑡𝑎𝑏𝑜𝑙𝑖𝑠𝑚 last month highlighted that some of the lactate is also 𝐜𝐨𝐧𝐯𝐞𝐫𝐭𝐞𝐝 𝐢𝐧𝐭𝐨 𝐥𝐚𝐜𝐭𝐨𝐩𝐡𝐞𝐧𝐲𝐥𝐚𝐥𝐚𝐧𝐢𝐧𝐞. The good news is that this molecule is a 𝐧𝐚𝐭𝐮𝐫𝐚𝐥 𝐚𝐩𝐩𝐞𝐭𝐢𝐭𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐚𝐧𝐭 that acts on the brain!

Appetite regulation is complex and involves 𝐬𝐞𝐯𝐞𝐫𝐚𝐥 𝐡𝐨𝐫𝐦𝐨𝐧𝐞𝐬 𝐚𝐧𝐝 𝐚𝐫𝐞𝐚𝐬 𝐨𝐟 𝐭𝐡𝐞 𝐛𝐫𝐚𝐢𝐧. Lactophenylalanine acts on the hypothalamus by inhibiting AgRP neurons, which activates neurons in the paraventricular nucleus of the hypothalamus and 𝐫𝐞𝐝𝐮𝐜𝐞𝐬 𝐟𝐞𝐞𝐥𝐢𝐧𝐠𝐬 𝐨𝐟 𝐡𝐮𝐧𝐠𝐞𝐫. The discovery of the metabolic action of lactophenylalanine potentially opens up new avenues for the 𝐭𝐫𝐞𝐚𝐭𝐦𝐞𝐧𝐭 𝐨𝐟 𝐜𝐞𝐫𝐭𝐚𝐢𝐧 𝐰𝐞𝐢𝐠𝐡𝐭-𝐫𝐞𝐥𝐚𝐭𝐞𝐝 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧𝐬.

Thus, physical activity would have a 𝐝𝐨𝐮𝐛𝐥𝐞 𝐩𝐨𝐬𝐢𝐭𝐢𝐯𝐞 𝐞𝐟𝐟𝐞𝐜𝐭 𝐨𝐧 𝐰𝐞𝐢𝐠𝐡𝐭 𝐥𝐨𝐬𝐬, burning calories during exercise while curbing hunger, which would otherwise cause the lost calories to be regained. It should be noted that in addition to its effects on weight, physical activity is also beneficial for 𝐦𝐞𝐧𝐭𝐚𝐥 𝐰𝐞𝐥𝐥-𝐛𝐞𝐢𝐧𝐠, 𝐩𝐡𝐲𝐬𝐢𝐜𝐚𝐥 𝐰𝐞𝐥𝐥-𝐛𝐞𝐢𝐧𝐠, 𝐬𝐥𝐞𝐞𝐩, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐧 𝐬𝐨𝐜𝐢𝐚𝐥 𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧 when performed in a group.