New article published: Harvengt et al., 2026

Congratulations to Prof. Lysy and his colleagues on the publication of their article in the journal Cells about the characterization of atypical diabetes as an intermediate form between type 1 diabetes (T1D) and monogenic diabetes in the pediatric population. We are delighted to have contributed to the success of this article!

Diabetes is a 𝐜𝐡𝐫𝐨𝐧𝐢𝐜 𝐜𝐨𝐧𝐝𝐢𝐭𝐢𝐨𝐧 caused by insufficient insulin production by the pancreas or by the body’s inefficient use of insulin. In 2022, 𝟏𝟒% 𝐨𝐟 𝐩𝐞𝐨𝐩𝐥𝐞 𝐮𝐧𝐝𝐞𝐫 𝐭𝐡𝐞 𝐚𝐠𝐞 𝐨𝐟 𝟏𝟖 had some form of diabetes, compared to 7% in 1990. T1D shares certain characteristics with other forms, such as 𝐦𝐨𝐧𝐨𝐠𝐞𝐧𝐢𝐜 𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬. The presence of 𝐢𝐧𝐭𝐞𝐫𝐦𝐞𝐝𝐢𝐚𝐭𝐞 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐞𝐬 complicates the differential diagnosis. In this article, the authors’ goal was to study the 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐜 𝐜𝐨𝐧𝐭𝐢𝐧𝐮𝐮𝐦 linking T1D and monogenic diabetes.

The 𝐆𝐄𝐍𝐄𝐏𝐄𝐃𝐈𝐀𝐁 study, which included diabetic patients aged 6 months to 18 years, was a multicenter, retrospective and prospective, interventional, and diagnostic study. The 𝐯𝐚𝐫𝐢𝐚𝐛𝐥𝐞𝐬 𝐬𝐭𝐮𝐝𝐢𝐞𝐝 were glycemic variability, parameters derived from continuous glucose monitoring, application of the DIAMODIA criteria, and genetic analyses. The authors demonstrated that the different forms of diabetes lie on a 𝐜𝐨𝐧𝐭𝐢𝐧𝐮𝐮𝐦 𝐨𝐟 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐞𝐬, with T1D and monogenic diabetes at the extremes of this continuum. Furthermore, the various 𝐟𝐨𝐫𝐦𝐬 𝐨𝐟 𝐚𝐭𝐲𝐩𝐢𝐜𝐚𝐥 𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬 𝐰𝐞𝐫𝐞 𝐬𝐢𝐭𝐮𝐚𝐭𝐞𝐝 𝐢𝐧 𝐭𝐡𝐞 𝐦𝐢𝐝𝐝𝐥𝐞 of this continuum, bridging the gap between T1D and monogenic diabetes.

Although 𝐠𝐞𝐧𝐞𝐭𝐢𝐜 𝐚𝐧𝐚𝐥𝐲𝐬𝐞𝐬 have not identified a variant responsible for atypical diabetes, several rare variants have been detected. These findings need to be validated in other cohorts to 𝐝𝐞𝐦𝐨𝐧𝐬𝐭𝐫𝐚𝐭𝐞 𝐭𝐡𝐞𝐢𝐫 𝐠𝐞𝐧𝐞𝐫𝐚𝐥𝐢𝐳𝐚𝐛𝐢𝐥𝐢𝐭𝐲, but they provide new insights for 𝐢𝐦𝐩𝐫𝐨𝐯𝐢𝐧𝐠 𝐭𝐡𝐞 𝐝𝐢𝐚𝐠𝐧𝐨𝐬𝐢𝐬 𝐚𝐧𝐝 𝐦𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 𝐨𝐟 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐰𝐢𝐭𝐡 𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬. The study is available on the journal’s website. DOI: 𝟏𝟎.𝟑𝟑𝟗𝟎/𝐜𝐞𝐥𝐥𝐬𝟏𝟓𝟎𝟓𝟎𝟒𝟖𝟒.