New published article: Pavone et al., 2025

Congratulations to Dr. Venkatasamy and colleagues on the publication of their article on the role of full-field optical coherence tomography (OCT) in the evaluation of lymph nodes in gynecological cancers in the journal Scientific Reports. We are delighted to have been able to contribute to the success of this article!

Assessing 𝐥𝐲𝐦𝐩𝐡 𝐧𝐨𝐝𝐞 (𝐋𝐍) 𝐬𝐭𝐚𝐭𝐮𝐬 is important in cancer management, particularly in the case of 𝐠𝐲𝐧𝐞𝐜𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐜𝐚𝐧𝐜𝐞𝐫𝐬, as it impacts surgical decisions, treatment, and prognosis. Current imaging techniques have 𝐥𝐢𝐦𝐢𝐭𝐚𝐭𝐢𝐨𝐧𝐬 in terms of scan time and spatial resolution. Although 𝐡𝐢𝐬𝐭𝐨𝐥𝐨𝐠𝐲 𝐢𝐬 𝐭𝐡𝐞 𝐠𝐨𝐥𝐝 𝐬𝐭𝐚𝐧𝐝𝐚𝐫𝐝, it takes time to produce results due to its complexity. 𝐅𝐮𝐥𝐥-𝐟𝐢𝐞𝐥𝐝 𝐎𝐂𝐓 has recently been shown to be effective in assessing LNs in breast and ovarian cancer.

The authors therefore tested the 𝐝𝐢𝐚𝐠𝐧𝐨𝐬𝐭𝐢𝐜 𝐚𝐜𝐜𝐮𝐫𝐚𝐜𝐲 𝐨𝐟 𝐟𝐮𝐥𝐥-𝐟𝐢𝐞𝐥𝐝 𝐎𝐂𝐓 in identifying metastatic LNs in patients with gynecological cancer, 𝐜𝐨𝐦𝐩𝐚𝐫𝐞𝐝 𝐭𝐨 𝐡𝐢𝐬𝐭𝐨𝐥𝐨𝐠𝐲. The analyses showed 𝐡𝐢𝐠𝐡 𝐚𝐜𝐜𝐮𝐫𝐚𝐜𝐲 (𝟗𝟕.𝟔%), 𝐬𝐞𝐧𝐬𝐢𝐭𝐢𝐯𝐢𝐭𝐲 (𝟗𝟐.𝟑%), 𝐚𝐧𝐝 𝐬𝐩𝐞𝐜𝐢𝐟𝐢𝐜𝐢𝐭𝐲 (𝟗𝟖.𝟐%) for full-field OCT. These results support the integration of full-field OCT into clinical practice to enable 𝐫𝐞𝐚𝐥-𝐭𝐢𝐦𝐞 𝐚𝐬𝐬𝐞𝐬𝐬𝐦𝐞𝐧𝐭 𝐨𝐟 𝐋𝐍 𝐩𝐫𝐨𝐠𝐫𝐞𝐬𝐬𝐢𝐨𝐧.

The combination of dynamic cellular imaging with full-field OCT could also reveal the 𝐦𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐜 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐲 𝐨𝐟 𝐭𝐮𝐦𝐨𝐫 𝐜𝐞𝐥𝐥𝐬. Research is actively continuing to improve full-field OCT, particularly with the help of 𝐚𝐫𝐭𝐢𝐟𝐢𝐜𝐢𝐚𝐥 𝐢𝐧𝐭𝐞𝐥𝐥𝐢𝐠𝐞𝐧𝐜𝐞-𝐛𝐚𝐬𝐞𝐝 𝐭𝐨𝐨𝐥𝐬. The article is available on the journal's website. doi: 𝟏𝟎.𝟏𝟎𝟑𝟖/𝐬𝟒𝟏𝟓𝟗𝟖-𝟎𝟐𝟓-𝟏𝟔𝟓𝟕𝟎-𝟗.