New published article : Borges et al., 2023
Congratulations to Dr. Lavalle and his colleagues on the publication in Advanced Healthcare Materials of their review article on recent advances in biomedical applications of layer-by-layer assemblies. We are delighted to have contributed to the success of this article!
The use of layer-by-layer assemblies began 30 years ago and aims at 𝐚𝐬𝐬𝐞𝐦𝐛𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐦𝐞𝐧𝐭𝐚𝐫𝐲 𝐩𝐨𝐥𝐲𝐞𝐥𝐞𝐜𝐭𝐫𝐨𝐥𝐲𝐭𝐞𝐬 𝐨𝐫 𝐛𝐢𝐨𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞𝐬 to form thin films. These nano-architectures have very precise compositions, structures, and physicochemical and biochemical properties. The technology is 𝐬𝐢𝐦𝐩𝐥𝐞, 𝐢𝐧𝐞𝐱𝐩𝐞𝐧𝐬𝐢𝐯𝐞, 𝐫𝐨𝐛𝐮𝐬𝐭, 𝐟𝐥𝐞𝐱𝐢𝐛𝐥𝐞, 𝐚𝐧𝐝 𝐡𝐢𝐠𝐡𝐥𝐲 𝐯𝐞𝐫𝐬𝐚𝐭𝐢𝐥𝐞, and can be applied to both 𝐦𝐞𝐭𝐚𝐥𝐥𝐢𝐜 𝐢𝐦𝐩𝐥𝐚𝐧𝐭𝐬 𝐚𝐧𝐝 𝐥𝐢𝐯𝐢𝐧𝐠 𝐜𝐞𝐥𝐥𝐬.
Over the last few decades, major innovations have been made concerning this technology and its specific applications in the biomedical field. This review article details the application of layer-by-layer assemblies in 𝐝𝐫𝐮𝐠 𝐝𝐞𝐥𝐢𝐯𝐞𝐫𝐲 𝐚𝐧𝐝 𝐭𝐢𝐬𝐬𝐮𝐞 𝐞𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐢𝐧𝐠. Possible uses in vaccinology, the creation of biomimetic tissue models, and bone and cardiac tissue engineering are also discussed.
Although the fundamental understanding of layer-by-layer assemblies and their industrial scalability needs to be improved, they are a 𝐡𝐢𝐠𝐡𝐥𝐲 𝐯𝐞𝐫𝐬𝐚𝐭𝐢𝐥𝐞 𝐭𝐨𝐨𝐥. Indeed, the 𝐩𝐨𝐬𝐬𝐢𝐛𝐢𝐥𝐢𝐭𝐢𝐞𝐬 𝐟𝐨𝐫 𝐚𝐝𝐚𝐩𝐭𝐚𝐭𝐢𝐨𝐧 𝐚𝐫𝐞 𝐚𝐥𝐦𝐨𝐬𝐭 𝐥𝐢𝐦𝐢𝐭𝐥𝐞𝐬𝐬, due to the wide variety of polymers, deposition conditions and bioactive molecules that can be added to layer-by-layer films. The article is already available on the journal's website! 𝐃𝐎𝐈: 𝟏𝟎.𝟏𝟎𝟎𝟐/𝐚𝐝𝐡𝐦.𝟐𝟎𝟐𝟑𝟎𝟐𝟕𝟏𝟑