New published article: Ebstein et al., 2024


Congratulations to Pr. Gounant and colleagues on the publication of their article on osteoporotic vertebral fractures (OVFs) in patients with non-small cell lung cancer (NSCLC) in the European Journal of Cancer. We are delighted to have contributed to the success of this article!

Lung cancer is the 𝐥𝐞𝐚𝐝𝐢𝐧𝐠 𝐜𝐚𝐮𝐬𝐞 𝐨𝐟 𝐜𝐚𝐧𝐜𝐞𝐫 𝐝𝐞𝐚𝐭𝐡 in France, with 52,777 new cases estimated in 2023. Lung cancer is divided into small-cell bronchial cancer (15%) and NSCLC (>80%). As therapies have increased the lifespan of patients with NSCLC, these patients also suffer from 𝐜𝐨𝐦𝐨𝐫𝐛𝐢𝐝𝐢𝐭𝐢𝐞𝐬 𝐬𝐮𝐜𝐡 𝐚𝐬 𝐨𝐬𝐭𝐞𝐨𝐩𝐨𝐫𝐨𝐬𝐢𝐬. The authors studied the 𝐩𝐫𝐞𝐯𝐚𝐥𝐞𝐧𝐜𝐞 𝐚𝐧𝐝 𝐢𝐧𝐜𝐢𝐝𝐞𝐧𝐜𝐞 of OVF during follow-up of NSCLC patients, as well as 𝐫𝐢𝐬𝐤 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 𝐚𝐧𝐝 𝐭𝐡𝐞 𝐢𝐦𝐩𝐚𝐜𝐭 𝐨𝐟 𝐎𝐕𝐅 on overall survival.

In a longitudinal retrospective cohort study of patients with NSCLC, OVFs were studied via computed tomography. The prevalence of OVF in the cohort of 289 patients was 𝟏𝟎.𝟕% 𝐚𝐭 𝐢𝐧𝐜𝐥𝐮𝐬𝐢𝐨𝐧 𝐚𝐧𝐝 𝟐𝟑.𝟐% 𝐚𝐭 𝐭𝐡𝐞 𝐞𝐧𝐝 𝐨𝐟 𝐟𝐨𝐥𝐥𝐨𝐰-𝐮𝐩 (median: 29.7 months). The incidence was 𝟒 𝐩𝐞𝐫 𝟏𝟎𝟎 𝐩𝐚𝐭𝐢𝐞𝐧𝐭-𝐲𝐞𝐚𝐫𝐬. 𝐈𝐧𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐧𝐭 𝐫𝐢𝐬𝐤 𝐟𝐚𝐜𝐭𝐨𝐫𝐬 were body mass index <19 kg/m2, low trabecular volumetric bone density, and corticosteroid use. OVF 𝐝𝐢𝐝 𝐧𝐨𝐭 𝐬𝐢𝐠𝐧𝐢𝐟𝐢𝐜𝐚𝐧𝐭𝐥𝐲 impact overall survival.

This article suggests that 𝐨𝐬𝐭𝐞𝐨𝐩𝐨𝐫𝐨𝐬𝐢𝐬 𝐬𝐡𝐨𝐮𝐥𝐝 𝐛𝐞 𝐬𝐜𝐫𝐞𝐞𝐧𝐞𝐝 in patients with NSCLC to enable better management of these patients The article is already available on the journal's website! 𝐃𝐎𝐈: 𝟏𝟎.𝟏𝟎𝟏𝟔/𝐣.𝐞𝐣𝐜𝐚.𝟐𝟎𝟐𝟒.𝟏𝟏𝟑𝟔𝟎𝟒