New published article: Messaaoui et al., 2023


Congratulations to Dr Messaaoui and colleagues on the publication in the journal Pediatric Diabetes of their article on hypoglycemia awareness status (HAS) in adolescents and children with Type 1 diabetes (T1D). We are delighted to have contributed to the success of this article!

HAS impairment involves a 𝐫𝐞𝐝𝐮𝐜𝐭𝐢𝐨𝐧 𝐨𝐫 𝐚𝐛𝐬𝐞𝐧𝐜𝐞 𝐨𝐟 𝐡𝐲𝐩𝐨𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐚 𝐰𝐚𝐫𝐧𝐢𝐧𝐠 𝐬𝐲𝐦𝐩𝐭𝐨𝐦𝐬 in patients with insulin-treated T1DM. This disorder is common in these patients, with a prevalence of 20-40% in the pediatric population. Given that impaired HAS is 𝐚𝐬𝐬𝐨𝐜𝐢𝐚𝐭𝐞𝐝 𝐰𝐢𝐭𝐡 𝐚𝐧 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐫𝐢𝐬𝐤 𝐨𝐟 𝐬𝐞𝐯𝐞𝐫𝐞 𝐡𝐲𝐩𝐨𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐚, the authors investigated the 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭 𝐭𝐫𝐚𝐣𝐞𝐜𝐭𝐨𝐫𝐢𝐞𝐬 𝐨𝐟 𝐇𝐀𝐒 in children and adolescents with T1D using flash glucose monitoring and the clinical implications of these different trajectories.

The patient cohort was composed of 255 patients, and 𝐟𝐨𝐮𝐫 𝐝𝐢𝐬𝐭𝐢𝐧𝐜𝐭 𝐇𝐀𝐒 𝐭𝐫𝐚𝐣𝐞𝐜𝐭𝐨𝐫𝐢𝐞𝐬 were identified: maintenance of normal HAS over time (T1), normal HAS restored during follow-up (T2), HAS impairment developed during follow-up (T3), and HAS impairment maintained over time (T4). No trajectory could be determined in 16 patients. The study showed that the 𝐫𝐢𝐬𝐤 𝐨𝐟 𝐬𝐞𝐯𝐞𝐫𝐞 𝐡𝐲𝐩𝐨𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐚 𝐝𝐞𝐩𝐞𝐧𝐝𝐞𝐝 𝐨𝐧 𝐭𝐡𝐞 𝐭𝐫𝐚𝐣𝐞𝐜𝐭𝐨𝐫𝐲 𝐟𝐨𝐥𝐥𝐨𝐰𝐞𝐝.

This article highlighted that HAS 𝐟𝐥𝐮𝐜𝐭𝐮𝐚𝐭𝐞𝐬 𝐨𝐯𝐞𝐫 𝐭𝐢𝐦𝐞 in a proportion of pediatric patients with T1D. Frequent assessment of HAS could 𝐢𝐦𝐩𝐫𝐨𝐯𝐞 𝐡𝐲𝐩𝐨𝐠𝐥𝐲𝐜𝐞𝐦𝐢𝐚 𝐫𝐢𝐬𝐤 𝐦𝐚𝐧𝐚𝐠𝐞𝐦𝐞𝐧𝐭 in young patients with T1D. The article is already available on the journal's website! DOI: 10.1155/2023/4882902.